Derrickson grew up in Denver, Colorado. He graduated from Biola University with a B.A. in Humanities with an emphasis on literature and philosophy, a B.A. in Communications with an emphasis on film, and a minor in theological studies. He earned his M.A. in film production from USC School of Cinematic Arts. Derrickson co-wrote and directed the film The Exorcism of Emily Rose, which was loosely based on a true story about Anneliese Michel. The film won the 2005 Saturn Award for Best Horror Film, and in 2006, was named in the Chicago Film Critics Association list of the Top 100 Scariest Films Ever Made. As of October 31, 2008, The Exorcism of Emily Rose had made over $140 million worldwide. Derrickson also directed The Day the Earth Stood Still starring Keanu Reeves and Jennifer Connelly, written by David Scarpa. The film was released in late 2008 and earned over $230 million worldwide.