Being born into a well-established and well-educated family doesn’t necessarily mean much. Despite such family accolades, Shue’s parents divorced while she was in the fourth grade. Owing to the occupational demands of her parents, Shue and her siblings found plenty of time to get into trouble in their suburban neighborhood, but Elisabeth soon enrolled in Wellesley College, an all-female institution which kept her out of trouble. During her studies, she found a way to make a little extra money by acting in television commercials. Elisabeth became a common sight in ads for Burger King, DeBeers diamonds, and Hellman’s mayonnaise. In 1984, she landed a role in the The Karate Kid (1984) as the on-screen girlfriend of Ralph Macchio and a role as the teenage daughter of a military family in the short-lived series "Call to Glory" (1984). At this time, Shue got herself an acting coach and transferred to Harvard, where she began studying political science.